Upasana Singh Thakuri, a rising talent in Nepali cinema, made her debut as a film actress in 2019 with Diwakar Bhattarai's sports drama "Captain." Starring alongside Anmol K.C. and Priyanka Mv, her portrayal received mixed reviews from critics. While she was acknowledged for playing her role well, some critics noted a challenge in expressing a range of emotions within the story.

However, Thakuri's career took an upward turn the same year with her role in Ram Babu Gurung's romantic comedy "Kabaddi Kabaddi Kabaddi." The film set a record for the highest-grossing opening in Nepali cinema and garnered praise for her performance. Critics lauded her improvement, noting her adept portrayal of various emotional situations with nuanced facial expressions, gestures, and dialogues.

Continuing her promising trajectory, Thakuri signed on for Pravin Jha's "December Falls" in 2021, co-starring with Aaryan Sigdel. Her dedication and contribution to Nepali cinema were recognized as she was honored with the National Navdurga Award, alongside other esteemed actresses, in the same year for her impactful role in the industry.